POLICE investigating the disappearance of Grafton woman Sharon Edwards now believe she has been murdered.

At a media conference outside Grafton Police Station yesterday afternoon Coffs Clarence crime manager Detective Inspector Darren Jameson said it was "more probable than not" the 55-year-old mother of three has met with foul play.

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Det Insp Jameson also said the focus of the investigation had moved from the last sighting of the woman between 10pm and 11pm on Saturday, March 14 at the Good Intent Hotel in South Grafton, to the Lawrence area between midnight and 7am on Sunday.

He said it appeared Mrs Edwards left the GI around 11pm and arrived at her home in Riverdale Court, Grafton, soon after, where she changed her clothes.

"Whether she did it of her own volition or there was some inducement, we can't say," he said.

Det Insp Jameson would not reveal how the police knew Mrs Edwards was in the Lawrence area at that time.

He said police were calling on members of the public to let them know of anything out of the ordinary they saw in the area north of Grafton around Lawrence.

"Often in these investigations it is the littlest piece of information that's crucial," he said.

Anyone with information on Mrs Edwards' whereabouts should phone the Grafton Police Station on 6642 0222 or Crime Stoppers on 1800 333 000.