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Cancer researchers accidentally find cure for baldness

Scientists already knew stem cells contained in a bulge area of hair follicles are involved in making hair and that SCF is important for pigmented cells.
Scientists already knew stem cells contained in a bulge area of hair follicles are involved in making hair and that SCF is important for pigmented cells.

A CREAM or ointment may soon cure baldness or stop hair turning grey, a new study suggests.

The cells that makes hairs and turns it grey was accidentally discovered by US scientists as they explored how certain cancer tumours form.

The breakthrough could one day identify possible treatments for balding and hair greying and also explain why we age, reported the Daily Telegraph.

When scientists deleted the SCF gene in the hair progenitor cells in mice, their hair turned white. When they deleted the KROX20-producing cells, no hair grew and the mice became bald.

Proffessor Le made the discovery while studying a disorder called Neurofibromatosis Type One, a rare genetic disease that causes tumours to grow on nerves.

Scientists already knew stem cells contained in a bulge area of hair follicles are involved in making hair and that SCF is important for pigmented cells.

What they did not know in detail was what happens after those stem cells move down to the base, or bulb, of hair follicles and which cells in the hair follicles produce SCF - or that cells involved in hair shaft creation make the KROX20 protein.

If cells with functioning KROX20 and SCF are present, they move up from the bulb, interact with pigment-producing melanocyte cells, and grow into pigmented hairs.

But without SCF, the hair in mouse models was grey, and then turned white with age, Without KROX20-producing cells, no hair grew.

Future research will try to find out if the KROX20 in cells and the SCF gene stop working properly as people age, leading to the greying and hair thinning seen in older people, as well as in male pattern baldness.

The research also could provide answers about why we age in general as hair greying and hair loss are among the first signs of ageing.

The study was published in Genes & Development.

- Daily Telegraph UK

Topics:  cancer editors picks general-seniors-news


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